Intracranial EEG (iEEG) affords unprecedented access to the human brain, permitting insight into human neurophysiology with high spatiotemporal and single-trial precision. However, iEEG is also limited due to brain coverage that is sparse within one patient and variable across patients. We present best practices to overcome this limitation, and propose that iEEG be considered a gold standard in studies of age-related and individual differences in the neurophysiology of human cognition. Chapter published in Intracranial EEG: A Guide for Cognitive Neuroscientists.
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